Status:
RECRUITING
OUD (Opioid Use Disorder) Target Trial
Lead Sponsor:
Duke University
Collaborating Sponsors:
Stanford University
Conditions:
Opioid Use Disorder
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In this research study the investigators will work with 80-participants with opioid use disorder who are starting treatment with the medication buprenorphine and are trying to quit using opioids. The...
Eligibility Criteria
Inclusion
- Age 18 or older; all genders included.
- Intellectual level sufficient to provide informed consent and accurately complete assessment instruments (English speaking/writing).
- Meet DSM-5 criteria for moderate or severe OUD. Individuals may also meet criteria for another substance use disorder (with the exception of alcohol or sedative/hypnotic); but must identify opioids as their primary substance.
- Starting buprenorphine and planning on opioid abstinence
Exclusion
- Pregnant, breast-feeding, or planning on getting pregnant.
- Alcohol or sedative/hypnotic use disorders (seizure risk).
- History of/or current psychotic disorder (e.g. schizophrenia).
- Current or lifetime bipolar disorder.
- Unstable Axis-I condition requiring starting a new medication.
- Active suicidal ideation / suicide attempt within 90 days.
- History of/or current dementia or other cognitive impairment.
- Contraindications to receiving rTMS or undergoing MRI (implanted ferromagnetic metal, history of or high risk of seizure, implanted device).
- Unstable general medical conditions.
Key Trial Info
Start Date :
December 31 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 31 2026
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06585709
Start Date
December 31 2024
End Date
October 31 2026
Last Update
January 9 2026
Active Locations (1)
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1
Duke University
Durham, North Carolina, United States, 27705