Status:
ENROLLING_BY_INVITATION
Exploring the Landscape of Somatic Mutations in Human Tissue
Lead Sponsor:
The Wellcome Sanger Institute
Conditions:
Somatic Mutation
Eligibility:
All Genders
18+ years
Brief Summary
Every cell in the human body contains a blueprint of the body called the genome. Throughout life, the genome can become damaged resulting in errors (mutations) that can change the way cells behave and...
Detailed Description
The investigators are seeking to characterise somatic mutations found in normal human tissue, as well as diseased tissue. These experiments have shown that a number of mutational processes previously ...
Eligibility Criteria
Inclusion
- Individuals undergoing surgery
- Individuals undergoing invasive procedures, e.g.
- Endoscopy (oesophagogastroduodenoscopy, small bowel enteroscopy, colonoscopy, sigmoidoscopy,proctoscopy) for suspected gastrointestinal disease, e.g. coeliac disease or for surveillance of known conditions/diseases.
- Tissue biopsy - of solid organs
- Prospective sampling will be carried out with the research participants\' consent.
Exclusion
- where consent has not been received
Key Trial Info
Start Date :
March 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 31 2026
Estimated Enrollment :
1800 Patients enrolled
Trial Details
Trial ID
NCT06585800
Start Date
March 1 2019
End Date
January 31 2026
Last Update
September 19 2024
Active Locations (1)
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1
Wellcome Sanger Institute
Cambridge, United Kingdom