Status:
RECRUITING
Intensive Treatment on Periodontitis in Aortic Stenosis
Lead Sponsor:
China National Center for Cardiovascular Diseases
Conditions:
Aortic Valve Stenosis
Periodontitis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this clinical trial is to determine if standardized periodontal therapy can effectively slow the progression of aortic valve stenosis in adult patients diagnosed with moderate aortic valve...
Eligibility Criteria
Inclusion
- Aged 18 years or older.
- Aortic valve peak velocity (Vmax) between 3.0 and 3.9 m/s.
- Diagnosis of aortic valve stenosis identified as degenerative aortic valve stenosis.
- Presence of gingivitis or mild-to-moderate periodontitis confirmed by periodontal probing or panoramic dental radiography.
- Willingness to participate in the study and signing of informed consent.
Exclusion
- End-stage renal disease with eGFR \< 15 ml/min/1.73m² (according to the Cockcroft \& Gault formula).
- Pregnant, breastfeeding, and women of childbearing age (except those with effective contraception).
- Factors that may affect study follow-up or adherence to periodontal therapy.
- Patients unwilling or unable to undergo comprehensive periodontal treatment.
- Patients who do not consent to participate in the study.
Key Trial Info
Start Date :
May 10 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2027
Estimated Enrollment :
920 Patients enrolled
Trial Details
Trial ID
NCT06587971
Start Date
May 10 2023
End Date
December 1 2027
Last Update
September 19 2024
Active Locations (1)
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1
China National Center for Cardiovascular Diseases
Beijing, Beijing Municipality, China, 100037