Status:
RECRUITING
Effect of Watermelon on Gut and Cardiometabolic Health
Lead Sponsor:
Florida State University
Conditions:
Obesity and Overweight
Dysbiosis
Eligibility:
All Genders
18-30 years
Phase:
NA
Brief Summary
The goal of this clinical trial is to evaluate the effect of daily fresh watermelon consumption for 6-weeks on gut health, including microbiome diversity, gut barrier and immune function in young adul...
Eligibility Criteria
Inclusion
- Between 18 and 30 years old
- Ability to speak and read in English
- Overweight or Obese Class 1 and 2 (BMI ≥ 25 - 39.9 kg/m2)
Exclusion
- Intake of antibiotics in the last 3 months
- Intake of pre/pro/postbiotics in the last 3 months
- Current or past (within the last 6 months) user of tobacco, marijuana, or E-cigarette products
- Cardiovascular disease (will not exclude for hypertension), gastrointestinal disease (ulcerative colitis, celiac, Crohn's disease, diverticulosis, peptic ulcers, small intestinal bacterial overgrowth, short bowel syndrome), neurological (multiple sclerosis, meningitis, recent stroke) or endocrine disorders (uncontrolled thyroid disorders, growth hormone disorders, adrenal gland disorders, uncontrolled diabetes - A1C greater than 9%).
- Food allergy to study foods
- Any allergy to melon
- Any allergy to the isocaloric snack (gluten)
- Regular consumption of watermelon greater than 2 servings / week
- Current heavy alcohol use (≥ 15 drinks / week for men, ≥ 8 drinks / week for women
- Class 3 Obesity (BMI \> 40 kg/m2)
- Current user of Citrulline, Arginine, Nitric Oxide or other supplements known to affect nitric oxide synthesis (beet root juice or any beet supplement, Pycnogenol / Pine bark extract)
- Known to be currently pregnant (self-disclosed)
Key Trial Info
Start Date :
October 13 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2026
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT06588218
Start Date
October 13 2024
End Date
August 1 2026
Last Update
October 15 2025
Active Locations (1)
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1
Florida State University - Gut Biome Lab
Tallahassee, Florida, United States, 32306