Status:
RECRUITING
Manual Versus AI-Assisted Clinical Trial Screening Using Large-Language Models
Lead Sponsor:
Brigham and Women's Hospital
Conditions:
Comparing Manual and AI Patient Screening in Heart Failure
Eligibility:
All Genders
18-90 years
Brief Summary
A prospective randomized controlled trial comparing manual review and AI screening for patient eligibility determination and enrollments. A structured query will identify potentially eligible patients...
Detailed Description
Screening participants for clinical trials is a critical yet challenging process that requires significant time and resources. Traditionally, patient screening has been manual, relying on the diligenc...
Eligibility Criteria
Inclusion
- Documented diagnosis of heart failure (e.g., ICD-9 codes 428 ICD-10 codes I50 or Problem list in the electronic health record)
- Most recent left ventricular ejection fraction (LVEF) assessed within the past 24 months
- Seen Mass General Brigham provider within the last 24 months
Exclusion
- LVEF \<50% currently prescribed or intolerant to an evidence-based beta-blocker, ARNI, MRA, and SGLT2i at least 50% goal dose
- LVEF\>50% currently prescribed or intolerant to SGLT2i
- Systolic blood pressure (SBP) \<90 mmHg at last measure
Key Trial Info
Start Date :
March 4 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 13 2024
Estimated Enrollment :
4500 Patients enrolled
Trial Details
Trial ID
NCT06588452
Start Date
March 4 2024
End Date
September 13 2024
Last Update
September 19 2024
Active Locations (1)
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1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115