Status:
RECRUITING
Establishment of Multiparametric Prediction Models for Moderate to SevereThyroid Associated Ophthalmopathy
Lead Sponsor:
Shanghai Changzheng Hospital
Conditions:
Thyroid Associated Ophthalmopathy
Eligibility:
All Genders
18-80 years
Brief Summary
Thyroid-associated ophthalmopathy (TAO) is an organ-specific autoimmune disease closely related to thyroid disease, which leads the incidence of orbital disease in adults and is the most common cause ...
Eligibility Criteria
Inclusion
- According to the Bartley criteria，diagnosed TAO at our hospital after 2024/8/31
- Moderate to severe patients defined by EUGOGO
- CAS ≥3 (on the 7-item scale) for the study eye
Exclusion
- Anticipated need for intervention due to sight-threatening complications or other significant and acute deterioration in vision
- History of systemic (eg, oral or IV) steroid use with a cumulative dose equivalent to \>1 g of methylprednisolone for the treatment of TAO.
- Any major illness/condition or evidence of an unstable clinical condition that, in the investigator\'s judgment, will substantially increase the risk to the participant, or confound the interpretation of safety assessments, if they were to participate in the study
- Any other condition that, in the opinion of the investigator, would impair the ability of the participant to comply with the study procedures or impair the ability to interpret data from the participant\'s participation in the study
- Pregnant or lactating
- Any other condition that,would impair the ability of the participant to undergo orbital MRI
- Incomplete information
Key Trial Info
Start Date :
October 9 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 6 2028
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06590220
Start Date
October 9 2024
End Date
September 6 2028
Last Update
June 24 2025
Active Locations (1)
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1
Shanghai Changzheng Hospital
Shanghai, Shanghai Municipality, China, 200003