Status:
NOT_YET_RECRUITING
Clemastine for Improving White Matter and Boosting Antidepressant Response in Late-life Depression
Lead Sponsor:
University of Illinois at Chicago
Collaborating Sponsors:
Cures Within Reach
Conditions:
Depression
Eligibility:
All Genders
60+ years
Phase:
PHASE2
Brief Summary
The goal of this study is to find out if the antihistamine, clemastine, can make the white matter in the brain better in older adults with depression. The study will also determine whether this improv...
Detailed Description
Geriatric depression, also known as late-life depression, is a type of major depression that affects people who are 60 years old or older. It can be difficult to treat and often comes back after treat...
Eligibility Criteria
Inclusion
- Age \> 60 years
- Diagnosis of major depressive disorder, single or recurrent episode (DSM5)
- Symptom Severity: MADRS ≥ 15
- Seeking antidepressant treatment
- Cognition score of MoCA \>24
- Fluent in English or Spanish
Exclusion
- Other Axis I psychiatric disorders, except for simple phobia or anxiety disorders present uniquely during the depressive episode (e.g., generalized anxiety disorder (GAD) or panic disorder symptoms)
- History of alcohol or drug dependence or abuse in the last year
- History of a developmental disorder or history of IQ (intelligence quotient) \<70
- Acute suicidality ideation within the past month as determined by the Columbia Suicide Severity Rating Scale (C-SSRS)
- Acute grief (\<1 month)
- Current or past psychosis
- Primary neurological disorder, including dementia, clinical stroke, brain tumor, epilepsy, etc.
- Presence of unstable medical illness requiring urgent treatment
- Any MRI contraindication
- Electroconvulsive Therapy (ECT) in last 6 months
Key Trial Info
Start Date :
September 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2026
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06591091
Start Date
September 1 2025
End Date
March 1 2026
Last Update
September 4 2025
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