Status:

RECRUITING

A Bundled Intervention

Lead Sponsor:

University of Alabama at Birmingham

Collaborating Sponsors:

National Institute on Drug Abuse (NIDA)

Conditions:

Opioid Use Disorder

Opioid Overdose

Eligibility:

All Genders

19+ years

Phase:

PHASE1

PHASE2

Brief Summary

Opioid overdose deaths have reached historically high records in the United States and are particularly concentrated among patients after emergency department (ED) discharge. Evidence-based treatment ...

Detailed Description

This study is supported by the HEAL Initiative (https://heal.nih.gov). Opioid overdose deaths have reached historically high records in the U.S. and are particularly concentrated among patients after ...

Eligibility Criteria

Inclusion Criteria:

  1. discharged from the ED and inpatient settings at the UAB hospital
  2. 19 years or older (the age of majority in Alabama);
  3. diagnosis of OUD and experiencing opioid overdose in the last 12 months;
  4. prescribed buprenorphine in the ED and willing to continue buprenorphine post-ED discharge;
  5. English speaking;
  6. not actively psychotic and suicidal, or cognitively impaired.
  7. Patients who are admitted to the hospital from the ED will be eligible for enrollment.

Exclusion Criteria:

  1. living in a restricted environment (e.g., prison or jail facility, etc.);
  2. currently enrolled in other clinical studies;
  3. anticipated to take other prescribed opioids except buprenorphine for a medical condition longer than three months;
  4. known allergic reaction to buprenorphine;
  5. critically ill or injured;
  6. females with pregnancy (they are anticipated to request a higher level of care).
  7. living outside of Alabama

Key Trial Info

Start Date :

February 13 2025

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

November 30 2030

Estimated Enrollment :

190 Patients enrolled

Trial Details

Trial ID

NCT06593093

Start Date

February 13 2025

End Date

November 30 2030

Last Update

February 23 2026

Active Locations (1)

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1

UAB

Birmingham, Alabama, United States, 35294