Status:
RECRUITING
Cardiac Radioablation for VT
Lead Sponsor:
Corewell Health East
Conditions:
Ventricular Tachycardia
Myocardial Infarction
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this interventional study is to determine the minimum dose necessary for successful cardiac radioablation of refractory ventricular tachycardia (VT) and to study the utility of target volu...
Detailed Description
This voluntary study is designed to learn what is the minimum dose of radiation therapy (RT) needed to successfully reduce the incidence of refractory ventricular tachycardia (VT) by half. Additionall...
Eligibility Criteria
Inclusion
- Participants must be 18 years or older.
- Automatic implanted cardiac defibrillator present.
- VT is monomorphic with at least two episodes of VT within an eight week (56 day) period as recorded by an AICD or heart failure related to VT or VT storm.
- Ejection fraction ≥20%.
- At least one previous cardiac ablation for VT.
- VT refractory despite antiarrhythmic medications.
- Likely to live for 12 months in the absence of VT.
- AICD in a position in the chest RT to be given without direct radiation.
- Woman of reproductive age must ensure that she won't become pregnant or breastfeed at the time of RT.
- The participant has no contraindications to a Cardiac MRI as per routine Cardiology practice.
Exclusion
- Class IV heart failure
- Abandoned leads.
- Prior radiation therapy to the chest or upper abdomen.
- Interstitial lung disease.
Key Trial Info
Start Date :
September 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT06593418
Start Date
September 1 2025
End Date
September 1 2026
Last Update
May 6 2025
Active Locations (1)
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1
Corewell Health William Beaumont University Hospital
Royal Oak, Michigan, United States, 48073