Status:
RECRUITING
Insulin Resistance and Coronary Microvascular Dysfunction in Patients with Myocardial Ischemia and Non-obstructive Coronary Artery Disease
Lead Sponsor:
Azienda Ospedaliera Universitaria Integrata Verona
Conditions:
Coronary Microvascular Dysfunction
Coronary Microvascular Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this prospective study is to assess the correlation between coronary microvascular disfunction and insulin resistance in patients with INOCA. Patients with ANOCA and without diabetes will...
Detailed Description
This is a prospective, experimental, single-center, explorative study designed to assess the correlation between coronary microvascular disfunction and insulin resistance in patients with INOCA. Pati...
Eligibility Criteria
Inclusion
- Aged over 18 years.
- Cardiac chest pain with evidence of myocardial ischemia at noninvasive myocardial stress imaging and clinical indication to diagnostic coronary angiography
- Willing and able to give informed consent for participation in the study
Exclusion
- Obstructive CAD (defined as more than 70% luminal stenosis and/or FFR ≤0.80 in 1 or more epicardial vessels).
- History of previous myocardial infarction, percutaneous revascularization or coronary-aortic bypass graft (CABG) surgery.
- Diagnosis of type II diabetes.
- BMI ≥ 35 kg/m2.
- Stage IV and V of chronic kidney disease (eGFR ≤ 30 ml/min, estimated through CKD - EPI Creatinine Equation).
- Allergy or other contraindication to iodinated contrast and/or gadolinium and/or adenosine.
- Chronic resting O2 saturation ≤ 85%.
- Pregnancy or suspected pregnancy.
Key Trial Info
Start Date :
June 24 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06597851
Start Date
June 24 2024
End Date
June 30 2026
Last Update
September 19 2024
Active Locations (1)
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1
Azienda Ospedaliera Universitaria di Verona
Verona, VR, Italy, 37126