Status:
COMPLETED
Effects of Low Lactose Milk Containing GOS on Digestive Response in Healthy Chinese Adults
Lead Sponsor:
Société des Produits Nestlé (SPN)
Collaborating Sponsors:
University of Nottingham
Conditions:
Healthy
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
We are aiming to assess the effects of low lactose milk containing galactooligosaccharides (GOS) on digestive response in healthy Chinese adults in comparison with a matching milk containing lactose.
Detailed Description
This is planned to be single-center, double-blind, randomized, 2x2 cross-over study. 24 healthy participants of Chinese ethnicity are planned to be enrolled. Participants will be invited to three vis...
Eligibility Criteria
Inclusion
- Participants declare that they are of Chinese ethnicity as well as both of their biological parents
- Women and men aged between 18 and 60 years
- Body mass index (BMI ≥ 18.5 \& \<30 kg/m2)
- Healthy: no medical conditions or previous gastrointestinal surgery which might affect study measurements (as declared by the participant)
- Able to understand and to sign written informed consent prior to study entry
- Informed consent signed
- Meets all the criteria for MRI Scan
- Can read and speak English
Exclusion
- Medically diagnosed milk allergy
- Subjects not willing and/or not able to comply with scheduled visits and the requirements of the study protocol
- Diagnosed with any gastrointestinal disorders
- History of claustrophobia
- Pregnant (defined by pregnancy test) or breast feeding
- History or current psychiatric illness
- History or current neurological condition (e.g. epilepsy)
- Consumption of \> 21 alcoholic drinks in a typical week (one serving is 0.4 dl of spirits, 1 dl of wine, or 3 dl of beer as declared by participant)
- Currently smoking (as declared by participant)
- Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance
- Antibiotic use within the 4 weeks preceding the intervention
- Probiotic \& prebiotics use within the 2 weeks preceding the intervention
Key Trial Info
Start Date :
August 20 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2025
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT06598124
Start Date
August 20 2024
End Date
June 30 2025
Last Update
November 24 2025
Active Locations (1)
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1
University of Nottingham
Nottingham, United Kingdom