Status:
NOT_YET_RECRUITING
Identification of Cutaneous and Blood Biomarkers Predictive of Response to Systemic Treatments During Chronic Inflammatory Skin Diseases
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Atopic Dermatitis
Psoriasis
Eligibility:
All Genders
18+ years
Brief Summary
Chronic inflammatory skin diseases constitute a heterogeneous group of pathologies. They affect the skin but also other organs (joints, lungs, muscles, etc.). Their prognosis and response to treatment...
Eligibility Criteria
Inclusion
- Patients:
- Age\>18 years
- Informed consent signed by the patient
- Diagnosis of moderate to severe chronic inflammatory skin disease (IGA score 3 or 4) including: atopic dermatitis, psoriasis, hidradenitis suppurativa, lichen planus, cutaneous lupus, dermatomyositis, cutaneous scleroderma (=morphea), neutrophilic dermatosis, cutaneous granulomatosis
- Or diagnosis of active leprosy (tuberculoid, lepromatous, reversion type 1, reversion type 2, hypersensitivity type 3), excluding pure neurological leprosy. Classification into 5 stages according to the Ridley and Jopling classification \[1\], Reversion reaction (type 1 reaction) and leprous erythema nodosum (type 2 reaction).
- Healthy controls :
- Age\>18 years
- Plastic surgery patients who have had any type of surgery resulting in healthy skin remnants
- Informed consent signed by the patient
- Absence of known cutaneous or systemic inflammatory disease.
Exclusion
- Under guardianship or curatorship
- Pregnant or breastfeeding woman
- Lack of affiliation with a social security system
- Systemic treatment in progress or received less than 3 months ago.
Key Trial Info
Start Date :
October 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2044
Estimated Enrollment :
700 Patients enrolled
Trial Details
Trial ID
NCT06599411
Start Date
October 1 2024
End Date
October 1 2044
Last Update
September 19 2024
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