Status:
ACTIVE_NOT_RECRUITING
Leveraging the Seasonal Malaria Chemoprevention Platform to Address Malaria and Malnutrition
Lead Sponsor:
University of California, San Francisco
Collaborating Sponsors:
Centre de Recherche en Sante de Nouna, Burkina Faso
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Malaria Incidence
Seasonal Malaria Chemoprevention
Eligibility:
All Genders
6-59 years
Phase:
NA
Brief Summary
In the Sahel, the malaria and malnutrition seasons overlap during the rainy season, from approximately July through October. Malaria transmission increases due to the rain and collection of standing w...
Eligibility Criteria
Inclusion
- Children will be eligible for inclusion in the trial if they meet all of the following criteria:
- Live in the study community
- Eligible for SMC
- No allergy to peanuts or cow's milk
- Able to orally feed
- Within the eligible age ranges:
- 6-59 months for passive surveillance
- 6-24 months for SQ-LNS provision
- Written informed consent from at least one caregiver
- Caregiver is at least 18 years of age
- Children will be recruited during normal distribution (via door-to-door delivery) for SMC, which occurs monthly during the malaria season (July through October).
- Children ages 3-6 months are eligible for SMC and will be included in nutritional screening and monitoring by default but will not be eligible for SQ-LNS, which is designed for children ages 6-24 months and will not be part of the passive surveillance.
- A random sample of children ages 6-24 months during the first month of distribution will be asked to participate in an active surveillance cohort. These children will be followed biweekly for screening for malaria with a rapid diagnostic test and temperature and monthly for dried blood spot and anthropometric measurements.
Exclusion
Key Trial Info
Start Date :
July 3 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 30 2026
Estimated Enrollment :
438 Patients enrolled
Trial Details
Trial ID
NCT06599593
Start Date
July 3 2025
End Date
October 30 2026
Last Update
November 17 2025
Active Locations (1)
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1
Centre de Recherche en Sante de Nouna
Nouna, Burkina Faso