Status:
ACTIVE_NOT_RECRUITING
The Effectiveness of Paracetamol Versus Ibuprofen in Management of Patent Ductus Arteriosus in Preterm Neonates
Lead Sponsor:
Arooj Khan
Conditions:
Patent Ductus Arteriosus in Preterm Infants
Eligibility:
All Genders
48-96 years
Phase:
NA
Brief Summary
This study aims to find and compare the effectiveness of paracetamol and ibuprofen in the closure of patent ductus arteriosus in preterm neonates. The study is being conducted at Department of Nurser...
Eligibility Criteria
Inclusion
- Neonates of gestational age more than 30 weeks and less than 37 weeks
- Neonates with birthweight of ≥1250g
- Neonates with postnatal age of 48-96 hours
- Neonates having one of the following echocardiographic criteria: a duct size \> 2mm, a left atrium-to-aorta ratio \>1.4, end diastolic reversal of blood flow in the aorta, or poor cardiac function in addition to clinical signs of patent ductus arteriosus
Exclusion
- Gestational age less than 30 weeks and more than 37 weeks
- Presence of major congenital abnormalities
- Right-to-left ductal shunting
- Life-threatening infection
- Grade III or grade IV intraventricular hemorrhage
- Platelet count of \<60000/mm3
- Hyperbilirubinemia requiring blood transfusion
- Persistent pulmonary hypertension
Key Trial Info
Start Date :
April 10 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 10 2024
Estimated Enrollment :
254 Patients enrolled
Trial Details
Trial ID
NCT06601114
Start Date
April 10 2024
End Date
October 10 2024
Last Update
September 19 2024
Active Locations (1)
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1
MTI, Khyber Teaching Hospital
Peshawar, Khyber Pakhtunkhwa, Pakistan, 25000