Status:
RECRUITING
Post-discharge Malaria Chemoprevention Implementation Trial in Benin
Lead Sponsor:
Institut de Recherche Clinique du Benin
Collaborating Sponsors:
Liverpool School of Tropical Medicine
Kenya Medical Research Institute
Conditions:
Severe Malaria
Severe Anaemia
Eligibility:
All Genders
Up to 9 years
Phase:
PHASE4
Brief Summary
The proposed research aims to conduct implementation trials in Benin, co-designed with national stakeholders, to evaluate different delivery strategies for optimizing health system delivery of post-di...
Detailed Description
Introduction : Severe anaemia is a major cause of morbidity and mortality in children in malaria-endemic areas of sub-Saharan Africa, accounting for a large fraction of paediatric hospitalisations and...
Eligibility Criteria
Inclusion
- Aged below 10 years of both sexes
- Hospitalised with severe anaemia or severe malaria: Initially hospitalised with haemoglobin below 5.0 g/dl or PCV below 15%, or requirement for blood transfusion for other clinical reasons on or during admission to the hospital, or severe malaria, defined as a requirement for parenteral artesunate in the opinion of the treating clinician and the presence of microscopy or RDT confirmed Plasmodium infection
Exclusion
- Recognised specific other causes of severe anaemia (i.e., trauma, haematological malignancy, known bleeding disorders, such as haemophilia)
- Sickle cell anaemia/sickle cell disease
- Body weight below 5 kg
- HIV infection and cotrimoxazole prophylaxis are not exclusion criteria
Key Trial Info
Start Date :
July 2 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
648 Patients enrolled
Trial Details
Trial ID
NCT06601712
Start Date
July 2 2025
End Date
December 31 2026
Last Update
July 24 2025
Active Locations (2)
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1
Goho Departmental Hospital Centre
Abomey, Benin
2
Centre Hospitalier Universitaire de la Mere et de l'Enfant Lagune (CHU-MEL)
Cotonou, Benin