Status:
NOT_YET_RECRUITING
The Mosaic Brain: a New Diagnostic Approach in Focal Epilepsies
Lead Sponsor:
Institute of Child Health
Collaborating Sponsors:
Great Ormond Street Hospital for Children NHS Foundation Trust
Conditions:
Epilepsy Intractable
Epilepsy in Children
Eligibility:
All Genders
6-18 years
Brief Summary
Overall, this observational cohort study aims to: 1. Improve our understanding of the genetic architecture of childhood focal epilepsies. 2. Develop a liquid biopsy of cerebrospinal fluid (CSF) and a...
Detailed Description
Epilepsy is characterised by recurrent epileptic seizures, and is the most common brain disease affecting children, significantly reducing their quality of life. Understanding the cause of epilepsy is...
Eligibility Criteria
Inclusion
- Children in the epilepsy surgery pathway at Great Ormond Street Hospital (GOSH) with a clear or suspected MRI lesion.
- All children undergoing SEEG at GOSH. Children for which consent was obtained from themselves or, if appropriate, from their legal representatives.
- Children in whom there are no clinical contraindication to having a lumbar puncture procedure pre-surgery.
- Both sexes.
- Under the age of 18.
Exclusion
- Children that although undergoing epilepsy treatment or testing for an ischaemic lesion.
- Children with malignant brain tumours.
- Children in whom there are contraindications to performing a lumbar puncture procedure.
Key Trial Info
Start Date :
October 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06602570
Start Date
October 1 2024
End Date
September 1 2026
Last Update
September 19 2024
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