Status:
COMPLETED
Effects of Exercise and Metformin on Methylglyoxal Levels in Prediabetic Individuals
Lead Sponsor:
Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Conditions:
Methylglyoxal
PreDiabetes
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
The aim of this study is to compare the effects of exercise, standard lifestyle changes and metformin on MGO in prediabetic individuals.
Detailed Description
There is no comparative study in the literature evaluating the effects of exercise and metformin on MGO in prediabetic patients. The aim of this study is to compare the effects of exercise, standard l...
Eligibility Criteria
Inclusion
- Patients who were newly diagnosed with prediabetes by Oral Glucose Tolerance Test (OGTT) and/or HbA1C,
- who were assessed as physically inactive (Level 1) according to the International Physical Activity Questionnaire
- who had sufficient motivation to participate in the exercise program (assessed by one-on-one interviews conducted by the researchers),
- who were deemed suitable to participate in the exercise program after a cardiac examination by a cardiologist (with resting electrocardiogram and questioning of cardiac symptoms, and advanced tests such as exercise electrocardiogram test when necessary),
- who had the same weight (±2.5 kg) for 6 months before participating in the study.
Exclusion
- having a serious medical condition that would prevent the person from participating in the exercise study (e.g. advanced malignancy or major neurological, psychiatric or endocrine disease, respiratory failure, etc.),
- having used metformin for 6 months before the study, having cardiovascular disease,
- heart failure, cancer, having a BMI \<19 kg/m2, receiving hormone replacement therapy,
- having a life expectancy of less than 1 year, being HIV positive, substance use,
- functional dependence, having an orthopedic disease that prevents physical activity,
- having cognitive impairment and other diseases that would affect the study results (respiratory diseases, muscle diseases, non-alcoholic fatty liver disease, etc.),
- using medications or supplements that would affect the study results.
Key Trial Info
Start Date :
April 8 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 7 2022
Estimated Enrollment :
96 Patients enrolled
Trial Details
Trial ID
NCT06603480
Start Date
April 8 2021
End Date
December 7 2022
Last Update
September 19 2024
Active Locations (1)
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1
Sultan 2. Abdülhamid Han Training and Research Hospital
Üsküdar, Istanbul, Turkey (Türkiye), 34660