Status:
NOT_YET_RECRUITING
Essential Amino Acids and Parkinsons Disease
Lead Sponsor:
University of Arkansas
Conditions:
Parkinson Disease
Eligibility:
All Genders
55-99 years
Phase:
PHASE1
Brief Summary
Parkinson's disease is a neuromuscular disease that is relatively common in elderly that has many potentials symptoms, including a variety of physical features that together reduce quality of life. Th...
Detailed Description
Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra and is the second most common neurodegenerative disease in older individuals. PD may involve a var...
Eligibility Criteria
Inclusion
- Age 55 years or older
- Clinical diagnosis of idiopathic Parkinson Disease
- Hoehn and Yahr stage 2-3
- Stable medication regimen with L-DOPA/carbidopa for at least 4 weeks prior to study entry
Exclusion
- Findings suggestive of atypical or secondary Parkinsonism, including cerebellar sign
- Use of anticoagulation drugs (including aspirin and Plavix) within one week of the protocol
- Allergy to lidocaine
- Supranuclear gaze palsy, apraxia, prominent autonomic failure, or other cortical signs
- Multiple strokes with stepwise progression of symptoms
- Neuroleptic treatment at time of study entry or time of onset of Parkinsonism
- Inability to walk without a cane or walker
- Deep brain stimulation
- Montreal Cognitive Assessment (MoCA) score \<18
- Use of investigational drugs
- Early Alzheimer's disease
- Frontotemporal dementia of dementia with Lewy bodies
- Major depression treated with SSRIs
- Individuals with auditory or visual hallucinations
- Individuals taking drugs that cause Parkinsonism like symptoms such as antipsychotics, anti-emetics, prokinectic and anti-seizure medications
Key Trial Info
Start Date :
January 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2027
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT06604065
Start Date
January 1 2026
End Date
December 1 2027
Last Update
July 8 2025
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