Status:
RECRUITING
Immunity Markers in Intensive Care Patients and Ventilator-associated Pneumonia
Lead Sponsor:
Centre Hospitalier Intercommunal Aix-Pertuis
Conditions:
Pneumonia, Ventilator-Associated
Eligibility:
All Genders
18+ years
Brief Summary
The goal of this observational study is to show the direct correlation between the occurrence of recurrence of VAP and postagressive immunoparalysis, monitored by HLA-DR rate below litterature-acknowl...
Detailed Description
The occurrence of ICU-acquired infections in patients admitted to the intensive care unit (ICU) results in increased morbidity and mortality, increased length of stay in the ICU, and also clearly incr...
Eligibility Criteria
Inclusion
- Patient over 18 years old
- Patient admitted in the Intensive Care Unit of the CHIAP
- Patient under mechanical ventilation
- Patient with infectious pneumonia
- Informed Consent Form (ICF) obtained from the patient or emergency ICF obtained from close relatives
- Patient beneficiary of French social security, whatever the regime
Exclusion
- Patient under 18 years old
- Patient with severe neutropenia (neutrophils \< 0.5 G/L)
- Patient under immunosuppressive treatment
- Use of corticosteroids (intravenous or oral) prior to ICU admission
- Use of therapeutic antibodies
- Onco-hematological disease (e.g. lymphoma, leukemia...) under treatment or treated in the 5 years prior to inclusion
- End of chemotherapy 6 months prior to inclusion
- Patients with innate or acquired immune deficiency (e.g., severe combined immunodeficiency, HIV or AIDS, at any stage)
- Patients with a decision to limit or discontinue active therapies, at the time of inclusion
- Patients with an estimated ICU stay of less than 48 hours
- Participation in an interventional study
- Patient deprived of their liberty
- Patient under tutorship or curatorship
- Pregnant or breastfeeding woman
Key Trial Info
Start Date :
October 4 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06607055
Start Date
October 4 2023
End Date
September 1 2025
Last Update
September 23 2024
Active Locations (1)
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1
Centre Hospitalier Intercommunal Aix-Pertuis
Aix-en-Provence, France, 13100