Status:
COMPLETED
Effect of Esketamine on Perioperative Negative Mood in Patients Undergoing Cardiac Valve Surgery
Lead Sponsor:
Chinese PLA General Hospital
Collaborating Sponsors:
Beijing Tiantan Hospital
The Sixth Medical Center of Chinese PLA General Hospital
Conditions:
Depression, Anxiety
Cardiac Surgery
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
A multicenter, randomized controlled, blinded prospective study to investigate the effects of esketamine on perioperative anxiety and depression in patients undergoing cardiac valve surgery.
Detailed Description
Undergoing surgery can be a traumatic and painful experience for patients, often causing negative moods such as anxiety and depression. The size and type of surgery significantly impact the occurrence...
Eligibility Criteria
Inclusion
- Age ≥18 years old, male or female
- Patients undergoing heart valve surgery
- Patients with ASA grade 1 to 4
- BMI between 18-30 kg/m²
- Able to participate in neuropsychological testing and receive follow-up visits
- Clearly understand and voluntarily agree to participate in the study and sign the informed consent form
Exclusion
- Patients with significant preoperative neuro-psychiatric disease and cognitive impairment
- Intellectual disability or a MiniMental State Examination (MMSE) score \<24, or a speech disorder that may compromise their ability to undergo preoperative assessments
- History of psychoactive drug abuse
- 5\. Preoperative combined severe hepatic insufficiency or renal insufficiency 6. Any contraindications to ketamine or esketamine, such as refractory hypertension or hyperthyroidism
Key Trial Info
Start Date :
September 23 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 30 2025
Estimated Enrollment :
142 Patients enrolled
Trial Details
Trial ID
NCT06608030
Start Date
September 23 2024
End Date
April 30 2025
Last Update
November 25 2025
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
First Medical center of Chinese PLA General Hospital
Beijing, Beijing Municipality, China, China
2
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China