Status:
ACTIVE_NOT_RECRUITING
Efficacy and Safety of TTM in Adults With ECPR.
Lead Sponsor:
Peking University Third Hospital
Conditions:
Cardiac Arrest
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Investigators hypothesize that there is a difference in the 30-day survival rate and good neurological outcome rate between two groups of cardiac arrest patients undergoing ECPR, one group receiving h...
Eligibility Criteria
Inclusion
- Patients aged ≥18 and ≤60 years;
- Patients with in-hospital and out-of-hospital cardiac arrest of any initial rhythm;
- Patients who have received cardiopulmonary resuscitation for \>10 minutes without achieving return of spontaneous circulation;
- Patients with a reversible cause of cardiac arrest (acute myocardial infarction, pulmonary embolism, all initial defibrillatable rhythm, cardiomyopathy);
Exclusion
- cardiac arrest due to trauma;
- pregnant and lactating women;
- unwitnessed cardiac arrest;
- out-of-hospital cardiac arrest not receiving CPR within 5 minutes;
- \> 60 minutes from the onset of cardiac arrest to the initiation of extracorporeal cardiopulmonary resuscitation;
- achievement of return of spontaneous circulation before the start of external cardiopulmonary resuscitation;
- intracranial hemorrhage or suspected intracranial hemorrhage;
- pre-existing neurologic impairment (CPC ≥ 3) prior to the onset of cardiac arrest;
- those with end-stage heart failure;
- those with new-onset cerebral hemorrhage or cerebral infarction;
- other vascular conditions such as severe plaque in bilateral femoral arteries that cause difficulty in tube placement;
- patients with combined malignant tumors;
- other serious diseases with a life expectancy of \<1 year;
- refusal to perform extracorporeal cardiopulmonary resuscitation and/or target temperature administrators.
- Temperature \<30°C.
Key Trial Info
Start Date :
November 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
146 Patients enrolled
Trial Details
Trial ID
NCT06608095
Start Date
November 1 2023
End Date
December 31 2026
Last Update
September 25 2024
Active Locations (1)
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1
Emergency Dept of Peking University Third Hospital
Beijing, Beijing Municipality, China, 100191