Status:
RECRUITING
Bupropion for Fatigue in End-stage Kidney Disease Patients on Hemodialysis
Lead Sponsor:
The University of Texas Health Science Center at San Antonio
Conditions:
End Stage Renal Disease
Fatigue
Eligibility:
All Genders
25-74 years
Phase:
PHASE1
PHASE2
Brief Summary
Fatigue is the most common symptom reported by end-stage kidney disease patients on maintenance hemodialysis. Unfortunately, there currently is no medical management for this overwhelming feeling of t...
Detailed Description
While taking part in this study, participants will be asked to complete study procedures with the researchers or study staff three times a week during routine dialysis visits. Collections of blood, ur...
Eligibility Criteria
Inclusion
- Male and female ESKD patients between aged 25-74 yrs on maintenance in-center hemodialysis procedure 3 times/week for ≥3 months with an arteriovenous fistula or graft.
- Blood hemoglobin of ≥10.0 g/dL based on most recent routine laboratory profile.
- Dialysis adequacy measured with Kt/V of ≥1.2
- Ability to understand and the willingness to sign a written informed consent document
Exclusion
- Currently on bupropion or hypersensitivity/ intolerance to bupropion by history and monoamine oxidase inhibitors.
- Diagnosis or history of eating disorders (bulimia or anorexia nervosa) and seizure.
- Pregnant, lactating, childbearing women
- History of post-acute COVID-19 syndrome
- Diagnosis of depression and/or on antidepressants and bipolar affective disorder
- Patient Health Questionnaire (PHQ)-9 score of ≥10
- Diagnosis of cognitive impairment including dementia
- Current participation in another interventional trial
- Scheduled for kidney transplantation in next 6 months
- Life expectancy \<6 months as judged by the attending nephrologist/primary care physician.
- Current or history of substance abuse or dependency.
Key Trial Info
Start Date :
February 2 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 30 2027
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT06609343
Start Date
February 2 2026
End Date
January 30 2027
Last Update
December 22 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University Hospital Dialysis Medical Center (DMC)
San Antonio, Texas, United States, 78229