Status:
RECRUITING
CtDNA-guided Selection of Adjuvant Chemotherapy Regimens for Elderly Colon Cancer Patients After Surgery: a Single-center, Randomized, Controlled Study
Lead Sponsor:
Zhejiang Cancer Hospital
Conditions:
Colon Cancer
Colon Cancer (stage II & III)
Eligibility:
All Genders
70-80 years
Phase:
PHASE3
Brief Summary
The goal of this clinical trial is to explore the disease-free survival period of elderly patients with high-risk stage II and stage III colon cancer based on ctDNA detection. The main questions it ai...
Detailed Description
This study is a prospective, randomized controlled trial designed to explore the disease-free survival period of elderly patients with high-risk stage II and stage III colon cancer based on ctDNA dete...
Eligibility Criteria
Inclusion
- Patients aged 70-80, both male and female are eligible;
- Patients with histopathologically confirmed stage II high-risk or stage III colon cancer;
- Patients with an ECOG score of ≤2;
- Patients who are required to undergo tissue genetic testing;
- Subjects who voluntarily participate in this study, sign the informed consent form, have good compliance, and cooperate with follow-up visits.
Exclusion
- Patients with one or more severe concomitant systemic diseases that, in the investigator\'s opinion, would impair the patient\'s ability to complete the study.
- Patients who have had a history of malignant tumors within 5 years.
- Any unstable systemic disease (including active infection, poorly controlled diabetes, poorly controlled hypertension, unstable angina, congestive heart failure, myocardial infarction within one year, severe arrhythmia requiring medical treatment, liver, kidney, or metabolic diseases).
- Patients suffering from severe mental illnesses.
- Patients who have participated in other clinical trials within 30 days prior to screening.
- Patients who are unable to undergo adjuvant chemotherapy.
Key Trial Info
Start Date :
July 3 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2034
Estimated Enrollment :
312 Patients enrolled
Trial Details
Trial ID
NCT06609551
Start Date
July 3 2024
End Date
December 31 2034
Last Update
September 24 2024
Active Locations (1)
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1
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China, 310000