Status:
RECRUITING
Efficacy and Safety of Ursodeoxycholic Acid in Reversing Gastric Intestinal Metaplasia
Lead Sponsor:
Yongquan Shi
Conditions:
Gastric Intestinal Metaplasia
Eligibility:
All Genders
18-75 years
Phase:
PHASE4
Brief Summary
The goal of this clinical trial is to investigate the efficacy of ursodeoxycholic acid in treating gastric intestinal metaplasia in Helicobacter pylori-negative adults. It will also learn about the sa...
Eligibility Criteria
Inclusion
- patients aged from 18 to 75 years old.
- patients with OLGIM stage Ⅱ-Ⅳ diagnosed by upper gastrointestinal endoscopy and histopathological examination within the last 3 months.
- patients without Helicobacter pylori infection, including patients who had successful Helicobacter pylori eradication before enrollment.
Exclusion
- a history of regular use (defined as at least once per week) of non-steroidal anti-inflammatory drugs (NSAIDs) and/or statins.
- a history of stomach surgery (including endoscopic submucosal dissection and endoscopic mucosal resection) or previously diagnosed malignant tumor.
- a history of heart failure, renal failure, liver cirrhosis or chronic hepatic failure; patients with contraindications or allergies to the drugs in this study.
- breastfeeding or pregnancy.
- a history of substance abuse or alcohol abuse within the past one year.
- patients with severe mental illness.
- refusal to undergo drug treatment.
- refusal to sign informed consent.
Key Trial Info
Start Date :
November 12 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 31 2026
Estimated Enrollment :
196 Patients enrolled
Trial Details
Trial ID
NCT06610760
Start Date
November 12 2024
End Date
October 31 2026
Last Update
December 5 2025
Active Locations (6)
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1
989 Hospital of PLA Joint Logistics Support Force
Pingdingshan, Henan, China
2
Ankang Central Hospital
Ankang, Shaanxi, China
3
Hanzhong 3201 Hospital
Hanzhong, Shaanxi, China
4
Shangluo Central Hospital
Shangluo, Shaanxi, China