Status:
NOT_YET_RECRUITING
Interleukin 6-guided Antibiotic Prescriptions in AECOPD Inpatients
Lead Sponsor:
Ningbo No. 1 Hospital
Conditions:
Chronic Obstructive Pulmonary Disease, COPD
Eligibility:
All Genders
40-80 years
Phase:
NA
Brief Summary
In this multicenter, prospective, randomized controlled study, we aimed to figure out, compared with the global chronic obstructive pulmonary disease initiative (GOLD) guideline -guided antibiotic the...
Detailed Description
Acute exacerbation is the first leading cause of hospitalization and mortality among patients with COPD. Infection of bacteria has been detected in 49.59% of patients with AECOPD. Antibiotic prescript...
Eligibility Criteria
Inclusion
- AECOPD patients admitted to hospitals
- The exacerbation has lasted for at least 24 hours but equal to or less than 21 days
- ≥40 years of age but no more than 80 years old
- With at least 10 pack-year history of smoking
- Able to provide written informed consent and ensure the completion of the trial
Exclusion
- Axillary temperature≥38°C
- Acute pneumonia identified by X-Ray or CT of the chest
- Severe respiratory failure requiring admittance to ICU
- Comorbidities require antibiotic therapy (i.e. infection at another site, systematic infection, active chronic inflammatory condition, specific viral infection)
- Immunosuppression status (i.e., patients with HIV infection, with malignant tumor of blood system, receiving chemotherapy)
- Concurrent diseases requiring corticosteroids (equivalent to 60mg prednisone/day or more than 30 days)
- Antibiotic use in the previous four weeks
- Current tracheotomy status
- Bronchiectasis of origin other than COPD
- Invasive mechanical ventilation
- Patients diagnosed malignant tumors
- Pregnant or lactating women, or women of childbearing age not using an acceptable method of contraception.
- Newly diagnosed pulmonary embolism
- Participation in another clinical trial
Key Trial Info
Start Date :
September 20 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2026
Estimated Enrollment :
440 Patients enrolled
Trial Details
Trial ID
NCT06612476
Start Date
September 20 2024
End Date
August 31 2026
Last Update
September 25 2024
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