Status:

RECRUITING

CARE-ID: Dynamics of Respiratory Infections in Children and Transmission in Households and Schools

Lead Sponsor:

The Hospital for Sick Children

Conditions:

SARS CoV 2 Infection

RSV Infection

Eligibility:

All Genders

1+ years

Brief Summary

Viral respiratory tract infections are very common in children. They contribute to missed time in school, work disruption for caregivers and can also cause severe illness requiring hospitalization and...

Eligibility Criteria

Inclusion Criteria:

Viral dynamics (primary outcome):

  • The child must be less than 18 years of age
  • Have a positive PCR sample for influenza, RSV or SARS-CoV-2,
  • Have any one of the symptoms listed to meet testing eligibility: fever, cough, shortness of breath, decreased or loss of taste or smell, muscle aches/joint pains (unusual, long lasting, not related to injury), extreme tiredness (unusual fatigue not otherwise explained), sore throat, runny or stuffy/congested nose, headache (new, unusual, long-lasting), nausea/vomiting and/or diarrhea, and
  • Be within 5 days of symptom onset

Household testing inclusion criteria (secondary outcome):

-Any individual in the same household (i.e. household contacts, defined as residing at the same address) as the individual testing positive by PCR for influenza, RSV, SARS-CoV-2, mycoplasma pneumoniae, or bordetella pertussis

Classroom testing inclusion criteria (secondary outcome):

-Any individual in the same classroom (i.e. classroom contacts) as the individual testing positive by PCR for influenza, RSV, SARS-CoV-2, mycoplasma pneumoniae, or bordetella pertussis (i.e. case identified through the THS program)

Exclusion Criteria:

Viral dynamics (primary outcome):

-Participants will be ineligible if they are more than 5 days from symptom onset

Key Trial Info

Start Date :

October 10 2024

Trial Type :

OBSERVATIONAL

Allocation :

ESTIMATED

End Date :

December 31 2026

Estimated Enrollment :

500 Patients enrolled

Trial Details

Trial ID

NCT06640387

Start Date

October 10 2024

End Date

December 31 2026

Last Update

November 26 2025

Active Locations (1)

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1

The Hospital for Sick Children (SickKids)

Toronto, Ontario, Canada, M5G 1X8