Inclusion Criteria:

• Participant having freely given his oral agreement.
• Participant with a major sickle cell syndrome, regardless of genotype (e.g. SS, SC, Sbeta).
• Participant with a sufficient command of spoken and written French to take the assessments, complete the questionnaires, follow the program sessions and carry out the home exercises.

Exclusion Criteria:

• Participant with one or more severe psychiatric pathologies (e.g. severe depression, psychosis) that could interfere with the conduct of the study, in particular the primary and secondary endpoints.
• Participants with another chronic pathology causing fatigue.
• Participants in vaso-occlusive crisis (VOC) or hospitalization.
• Participant under legal protection (guardianship, curatorship, safeguard of justice, deprived of liberty).