Status:

RECRUITING

Cannabis Observations on Brain Waves, Retrieval, and Attention: Experiment 3

Lead Sponsor:

L. Cinnamon Bidwell

Collaborating Sponsors:

National Institute on Drug Abuse (NIDA)

Conditions:

Cannabis

Memory

Eligibility:

All Genders

21-40 years

Brief Summary

This study investigates the impact of ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on recognition memory in healthy, regular cannabis users. Participants complete the same recognition memory ta...

Detailed Description

Previous research has established cannabis's harmful cognitive impact, with particularly robust and consistent effects in the domain of episodic memory. However, prior work has not sufficiently consid...

Eligibility Criteria

Inclusion Criteria:

  1. Must be between the ages of 21 and 40 and provide informed consent;
  2. Must be right-handed (Laterality Quotient > 60 on Edinburgh Handedness Inventory - Short Form);
  3. Must use cannabis at least 4 days during the month;
  4. Must be a cannabis user for at least a year;
  5. Must self-report not using other illicit recreational drugs (e.g., cocaine, benzodiazepines (non-prescription), opiates (non-prescription), MDMA, sedatives, or methamphetamine) in the past 30 days, during the Pre-Screening;
  6. Must not test positive on a urine toxicology test for drugs of abuse at the Baseline appointment;
  7. Must not be using psychotropic medications, however anti-depressant, non-benzodiazepine anti-anxiety, and ADHD medications are ok. ADHD medication users must be willing to abstain from ADHD medication use on appointment days;
  8. Must not be a regular nicotine user (≤4 days per week; cigarette, E-cigs, or smokeless);
  9. Must not have used caffeine or nicotine (cigarette, E-cigs, or smokeless) for 4 hours before each appointment;
  10. Must have a breath alcohol level of 0 at Baseline appointment (to sign consent form);
  11. Must not be actively seeking or in treatment for any substance use disorder;
  12. Female subjects must not be or trying to become pregnant (as indicated by a pregnancy test administered at Baseline appointment);
  13. Must not be in treatment for psychotic disorder or bipolar disorder; or have a history with these disorders;
  14. Must not have any physical characteristics (e.g., thick hair, head size exceeding the limit of the net, dyed hair) or experience any technical difficulties during testing that result in a poor-quality EEG recording.

Key Trial Info

Start Date :

October 9 2024

Trial Type :

OBSERVATIONAL

Allocation :

ESTIMATED

End Date :

January 1 2026

Estimated Enrollment :

64 Patients enrolled

Trial Details

Trial ID

NCT06669585

Start Date

October 9 2024

End Date

January 1 2026

Last Update

December 9 2024

Active Locations (1)

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1

Center for Innovation and Creativity (CINC)

Boulder, Colorado, United States, 80301

Cannabis Observations on Brain Waves, Retrieval, and Attention: Experiment 3 | DecenTrialz