Status:

RECRUITING

A Danish Pragmatic Randomized Trial of Nutritional Supplements in Heart Failure

Lead Sponsor:

Tor Biering-Sørensen

Collaborating Sponsors:

Pharma Nord

Conditions:

Heart Failure

Eligibility:

All Genders

18+ years

Phase:

PHASE3

Brief Summary

Heart failure is a common and serious condition. Despite rapid advancements in heart failure treatment, the prognosis remains severe. Smaller studies have shown that two simple, safe, and relatively i...

Detailed Description

This investigator-initiated, pragmatic, registry-based, double-blinded, placebo-controlled, 2x2 factorial, individually randomized trial aims to evaluate the efficacy of daily intake of the nutritiona...

Eligibility Criteria

Inclusion Criteria:

  • Individuals aged ≥ 18 years.
  • Registered with a heart failure diagnosis (ICD-10: I50) as a primary discharge diagnosis in The Danish National Patient Registry and at least one claimed prescription of a renin-angiotensin-system inhibitor and a β-blocker within 120 days after HF diagnosis.
  • Informed consent form has been signed and dated.

Exclusion Criteria:

  • Use of vitamin K-antagonist
  • Registered with a cancer diagnosis (C00-C97 not C44) within the last 5 years excluding cutaneous squamous cell or basal cell carcinoma in The Danish National Patient Registry.

Key Trial Info

Start Date :

September 30 2025

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

June 1 2029

Estimated Enrollment :

4044 Patients enrolled

Trial Details

Trial ID

NCT06694727

Start Date

September 30 2025

End Date

June 1 2029

Last Update

October 3 2025

Active Locations (1)

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Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte

Hellerup, Denmark, 2900

A Danish Pragmatic Randomized Trial of Nutritional Supplements in Heart Failure | DecenTrialz