Status:

RECRUITING

A Clinical Study of Evaluating Myocardial Viability in Ischemic Heart Disease with Integrated 18F-FDG PET/MR

Lead Sponsor:

Shanghai East Hospital

Conditions:

Ischemic Heart Disease

Eligibility:

All Genders

Up to 80 years

Brief Summary

The main purpose is to evaluate the accuracy of myocardial imaging obtained through integrated 18F-FDG PET/MR in detecting viable myocardium. The secondary objective is to evaluate whether myocardial ...

Detailed Description

A comprehensive evaluation of the degree of coronary artery stenosis, myocardial ischemia range, and survival status are required before surgery, which can help predict postoperative efficacy and sele...

Eligibility Criteria

Inclusion Criteria:

  1. Adults under the age of 80
  2. Coronary angiography shows coronary artery disease, with at least 2 coronary arteries having a degree of stenosis greater than 80%
  3. ft ventricular ejection fraction (LVEF)<40%
  4. Acute myocardial infarction onset for at least 3 months
  5. Patients with old myocardial infarction with no acute coronary artery events in the past 3 months
  6. Patients of pre implementation of coronary artery bypass grafting (CABG) or combined treatment with human umbilical cord mesenchymal stem cells (iPSC)
  7. Agree to participate in this clinical trial and sign an informed consent form
  8. Good compliance

Exclusion Criteria:

  • 1.Patients with diabetes or other patients with poor blood glucose control (fasting blood glucose value on the test day is greater than 10mmol/L) 2.Patients who allergy to MR contrast agent 3.Electronic implants such as pacemakers, nerve stimulators, insulin pumps, cochlear implants 4.Patients who have undergone aneurysm surgery and have intracranial aneurysm clips 5.Patients who have undergone heart surgery and have an artificial heart valve 6.Patients with metal foreign objects in the eyes 7.Patients with metal implants and prostheses, or metal foreign bodies in other parts of body 8.Severe liver and kidney dysfunction 9.Accompanied by arrhythmia such as atrial fibrillation, cerebrovascular disease, and severe pulmonary heart disease 10.Pregnant or plan to pregnant within three months or lactating women 11.Critically ill patients who require the use of life support systems 12.Patients with claustrophobia 13.Other situations which clinical trial personnel deem it inappropriate to participate in this trial

Key Trial Info

Start Date :

December 31 2025

Trial Type :

OBSERVATIONAL

Allocation :

ESTIMATED

End Date :

December 31 2026

Estimated Enrollment :

100 Patients enrolled

Trial Details

Trial ID

NCT06712862

Start Date

December 31 2025

End Date

December 31 2026

Last Update

December 2 2024

Active Locations (1)

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1

Shanghai East Hospital

Shanghai, Shanghai Municipality, China, 200120

A Clinical Study of Evaluating Myocardial Viability in Ischemic Heart Disease with Integrated 18F-FDG PET/MR | DecenTrialz