Inclusion Criteria:

• Symptomatic blepharitis.
• At least 6 years of age.
• Eyelid collarette count (minimum score 2).
• Willing and able to follow all instructions and attend all study visits.
• Able to avoid prohibited medication for the duration of the study.
• Patients can willingly provide consent or have a legal authorized representative provide consent on the informed consent (IC) Form.

Exclusion Criteria:

• Women with confirmed pregnancies.
• Utilizing any current medical therapy for the eye.
• History of allergic reaction to spinosad or any formulation component.
• Patients using eyelid hygiene or other treatment(s) for blepharitis within 14 days of screening.
• History of ocular surgery within the past 1 year.
• Presence of other ocular diseases that may affect study outcomes (Corneal Dystrophies, Salzmanns disease, Severe dry eye, Keratoconus, Glaucoma filtering blebs).
• Use of investigational drug, chronic glaucoma medications, steroid.
• Uncontrolled systemic disease.
• Acute or chronic illness that would confound study results.