Patient inclusion criteria :

• Diagnosed with severe Mediterranean anemia, with no restrictions on alpha and beta types;

• Age between 7-12 years old, male or female not limited; Weight<40kg

• The patient has or does not have HLA matched or semi matched donors, but unconditionally transplants or refuses to undergo blood stem cell transplantation treatment; And patients who unconditionally or refuse to undergo gene therapy for thalassemia;

• There are HLA matched or mismatched donors who meet the donor criteria through physical examination;

• The patient and their family agree to receive super transplantation treatment and sign a written informed consent form before the transplantation trial.

  （2） Exclusion criteria for patients:

• Psychiatric patients;

• Participants in clinical trials of other drugs within the past month;

• There are no suitable HLA mismatched donors available.

• Other researchers have determined that they are not suitable to participate in this study.

  （3） Supplier screening criteria:

• HLA typing matches the patient's haplotype

• KIR configuration

• NIMA

• DSA negative

• Routine physical examination

• Genetic screening for carriers of thalassemia, mild or no carriers of thalassemia

• Sign the informed consent form.