Status:

RECRUITING

Leprosy Active Searching Trial in Brazil

Lead Sponsor:

Hospital Alemão Oswaldo Cruz

Conditions:

Leprosy

Eligibility:

All Genders

Phase:

NA

Brief Summary

The goal of this clinical trial is to assess whether a multifactorial active case-finding strategy improves the detection of leprosy cases in Brazil compared to usual screening practices. The main que...

Eligibility Criteria

Inclusion Criteria:

(I) Municipalities

  • Municipality recognized by the Brazilian Institute of Geography and Statistics as part of the Brazilian Federation.
  • Municipality with operational epidemiological classification by the Ministry of Health (BMoH) as: 'municipalities with cases in the period from 2015 to 2019'.
  • Municipality with authorization/consent from the government to participate in the study.

(II) Primary Health Units (Unidade Básica de Saúde or UBS) • UBS with territorial coverage (linked population) within the participating municipality.

(III) Participants

• Patients with positive Leprosy Suspicion Questionnaire (LSQ): children under five years old with Free and Informed Consent Form (ICF) signed by parents/guardians, 5-17 years old with ICF signed by parents/guardians and Free and Informed Assent Form (IAF) signed by the minor, and patients over 18 years old with ICF signed for: rapid test collection, comorbidity questionnaire and clinical evaluation; and if leprosy diagnosis is confirmed, collection of complementary exams.

Exclusion Criteria:

(I) Municipalities

  • Municipality with extreme population size (municipalities with a number of inhabitants lower than the 10th percentile and higher than the 90th percentile).
  • Municipality with operational epidemiological classification by the BMoH as: 'municipalities without cases in the period 2015 to 2019'.
  • Municipalities with active or recent participation (less than one year) in other active-finding strategies, in addition to the usual ones: ministerial, Non-Governmental Organizations (NGOs), academic, among others.

(II) Primary Health Units

  • UBS with limited multidisciplinary team (absence of physicians, nurse and/or community health agents).
  • UBS with difficult access (no access by land, i.e. riverside populations).
  • UBS with territorial coverage exclusively of indigenous populations.

(III) Participants

  • LSQ negative.
  • Patients with a previous diagnosis or history of treated leprosy.
  • Patients residing/registered outside the selected municipality.

Key Trial Info

Start Date :

June 1 2025

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

May 31 2026

Estimated Enrollment :

1925 Patients enrolled

Trial Details

Trial ID

NCT06761469

Start Date

June 1 2025

End Date

May 31 2026

Last Update

July 2 2025

Active Locations (1)

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1

Hospital Alemão Oswaldo Cruz

São Paulo, São Paulo, Brazil, 01327-001