Status:
RECRUITING
"The Effect of Inhaled Nitroglycerin for COPD Patients
Lead Sponsor:
Beni-Suef University
Conditions:
COPD
COPD III/IV
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
this study aims to investigative the benefits of using nebulized nitroglycerin in improving respiratory functions in patients of late stage COPD
Detailed Description
the inhaled nitroglycerin is expected to make vasodilatation of the pulmonary arteries and arterioles which are constricted in late stages of COBD leading to ventilation/perfusion mismatching and furt...
Eligibility Criteria
Inclusion Criteria:
- Adult patient's ≥ 18 years old COPD exacerbation with respiratory failure and Echo evidenced presence of pulmonary hypertension (defined as mean pulmonary artery pressure > 20 mmHg)
Exclusion Criteria:
- Profound left ventricular failure, as the decrease in pulmonary vascular resistance results in an increase in left ventricular preload. This may worsen cardiogenic pulmonary edema.
- Pregnant female patients
- Patient with hypersensitivity to nitroglycerin
Key Trial Info
Start Date :
February 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06785337
Start Date
February 1 2025
End Date
December 1 2025
Last Update
January 23 2025
Active Locations (1)
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1
Haram Hospital
Haram, Giza Governorate, Egypt, 12556