Status:
ACTIVE_NOT_RECRUITING
The Significance and Indications of Surgery for Synchronous Liver Metastatic Pancreatic Cancer
Lead Sponsor:
China-Japan Friendship Hospital
Collaborating Sponsors:
Peking University First Hospital
Chongqing General Hospital
Conditions:
Pancreatic Cancer
Liver Metastases
Eligibility:
All Genders
18-75 years
Brief Summary
To explore the clinical characteristics of pancreatic cancer patients with liver metastases who can benefit from surgery, and to develop evaluation criteria for surgical indications, so as to provide ...
Detailed Description
Initial Systemic Treatment: Subjects who meet the inclusion criteria will first undergo systemic treatment. The primary treatment regimens will follow the NCCN guideline-recommended first-line chemoth...
Eligibility Criteria
Inclusion
- Age 18-75 years old
- Pancreatic cancer was diagnosed as pancreatic ductal adenocarcinoma by biopsy of primary/metastases
- Physical Condition Score (ECOG)0-1
- Simultaneous/prior discovery of liver metastases and primary lesions was defined as simultaneous liver metastases
- Enhanced CT/MRI can detect liver metastases (if the diseases not detected by enhanced CT/MRI during screening are not included in the number calculation)
- The patient's liver, kidney and bone marrow function is good
Exclusion
- The primary lesions of pancreatic cancer are acinar cell carcinoma of pancreas, neuroendocrine carcinoma of pancreas and other pathological types
- there are other metastases outside the liver
- Had other malignant tumors within 5 years
- History of central nervous system disease, mental illness, unstable angina pectoris, congestive heart failure, severe arrhythmia and other serious diseases
- Active or chronic hepatitis B/C virus infection
- Allergy to iodine, unable to perform enhanced imaging
- Previous anti-tumor therapy for pancreatic cancer (surgery/ radiotherapy/ chemotherapy/ ablation/ targeted therapy/ immunotherapy)
Key Trial Info
Start Date :
August 23 2024
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 30 2026
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06873178
Start Date
August 23 2024
End Date
June 30 2026
Last Update
April 16 2025
Active Locations (1)
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1
China-Japan Friendship Hospital
Beijing, Beijing Municipality, China, 100029