Status:
RECRUITING
Holmium-166 Transarterial Radioembolization for the Treatment of Hepatocellular Carcinoma
Lead Sponsor:
Universitair Ziekenhuis Brussel
Conditions:
Locally Advanced Hepatocellular Carcinoma
Liver Cirrhosis
Eligibility:
All Genders
18+ years
Brief Summary
This study aims to evaluate the effectiveness and safety of Holmium-166 (Ho-166) transarterial radioembolization (TARE) for treating patients with locally advanced hepatocellular carcinoma (HCC), a co...
Detailed Description
This study investigates the use of Holmium-166 (Ho-166) transarterial radioembolization (TARE) as a treatment for patients with locally advanced hepatocellular carcinoma (HCC), a primary liver cancer....
Eligibility Criteria
Inclusion
- aged 18 year or older
- diagnosed with locally advanced HCC without extra-hepatic metastases
- HCC must not be amendable to treatment by surgical resection or percutaneous radiofrequency ablation
- after assessment by the investigator and multidisciplinary tumor board, the patient is considered suitable for protocol treatment with Holmium-166 TARE
- ECOG performance status 0-2
- child-Pugh A-B
- tumor response evaluable with mRECIST criteria during follow-up
Exclusion
- prior treatment with any of the following treatment modalities for HCC: systemic therapy, hepatic radiation therapy
- currently enrolled in clinical studies where patient receive investigational therapeutic drug
- metastatic disease
- concurrent malignancy
- active contra-indications to angiography or selective catherization (i.e. severe vascular disease or bleeding diathesis)
- uncontrolled and/or severe comorbidities (active infection, heart failure,...) with limited estimated life expectancy
- history of or know allergic reactions to used compounds
Key Trial Info
Start Date :
February 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06873269
Start Date
February 1 2025
End Date
February 1 2026
Last Update
March 12 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
UZ Brussel
Brussels, Belgium