Status:
RECRUITING
Assessing Declined Liver Grafts With Normothermic Machine Perfusion to Reduce Transplant Waiting Time
Lead Sponsor:
Charite University, Berlin, Germany
Collaborating Sponsors:
German Research Foundation
Conditions:
Liver Transplantation
Liver Diseases
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this study is to find out if quality assessment by normothermic machine perfusion can be used to safely increase the number of usable donor livers, helping more people get transplants fast...
Detailed Description
Liver transplantation is the treatment of choice for patients with advanced liver cirrhosis, hepatocellular carcinoma within the Milan criteria, and severe metabolic or autoimmune liver diseases. Howe...
Eligibility Criteria
Inclusion
- Able to consent
- ≥ 18 years old
- Listed in status "transplantable" by the transplant conference of the study centre for liver transplantation, according to the guidelines of the German Medical Association valid at the time of inclusion
- ReMELD-Na-Score ≤ 21 (equivalent to MELD ≤25), not eligible for \[non\]standard exceptions
- Medically suitable and informed for transplantation with an organ that fulfils extended donor criteria (Eurotransplant ECD criteria)
- Patient information and written consent to participate in the Extra trial
- No participation in another interventional study during participation
Exclusion
- Listed for retransplantation
- High-Urgency Listing
- Listed for combined organ transplantation
- Pregnancy
Key Trial Info
Start Date :
June 2 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2030
Estimated Enrollment :
186 Patients enrolled
Trial Details
Trial ID
NCT06874296
Start Date
June 2 2025
End Date
December 31 2030
Last Update
December 5 2025
Active Locations (5)
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1
University Medical Center Hamburg-Eppendorf
Hamburg, Hamburg, Germany, 20251
2
University Hospital RWTH Aachen
Aachen, North Rhine-Westphalia, Germany, 52074
3
University Hospital Bonn
Bonn, North Rhine-Westphalia, Germany, 53127
4
University Hospital Muenster
Münster, North Rhine-Westphalia, Germany, 49149