Status:
RECRUITING
Comparison of Dairy and Plant-based Alternatives in Adolescents and Older Adults
Lead Sponsor:
University of Toronto
Conditions:
Glycemic Response to Feeding in Healthy Participants
Postprandial Amino Acid Concentrations
Eligibility:
All Genders
14-75 years
Phase:
NA
Brief Summary
The purpose of the Dairy vs Plant study is to compare the effects of dairy and plant-based alternative products on blood sugar regulation and nutrient quality in adolescents and older adults. We are i...
Eligibility Criteria
Inclusion
- Age 14-18 years old (adolescents) or 60-75 years old (older adults)
- BMI z-score \>+1SD, \<+2SD (adolescents) or BMI 25-30 kg/m2 (older adults)
- Willing to maintain habitual diet, physical activity pattern, and body weight throughout the study.
- Willing to maintain current dietary supplement use throughout the study. On study visit days, subject agrees not to take any supplements until dismissal from the Nutrition Intervention Center.
- Willing to abstain from alcohol consumption for 24hrs prior to all study visits.
- Willing to avoid vigorous physical activity for 24hrs prior to all study visits.
- Willing to refrain from cannabis use throughout the entire duration of the study.
- Willing to refrain from protein supplement use (e.g. protein powder) throughout the entire duration of the study.
- Understands the study procedures, provides informed consent to participate in the study, and authorizes release of relevant protected health information to the study investigator.
Exclusion
- Smoking
- Thyroid problems
- Lactose intolerance and/or allergies, intolerances, or sensitivities to study treatments
- Previous history of cardiovascular disease, diabetes, liver or kidney disease, inflammatory bowel disease, celiac disease, short bowel syndrome, malabsorptive syndrome, pancreatitis, gallbladder or biliary disease
- Presence of gastrointestinal disorder or surgeries within the past year.
- Inability to comply with the experimental procedures and follow our safety guidelines
- Regular breakfast skipping (\>3 days a week)
- On a special diet (e.g. ketogenic, Atkins, high protein) or restrained eaters as identified by a score of \>20 on the Eating Attitudes Questionnaire
- Difficulties with eating or swallowing
- Fasting blood glucose \>5.6mmol/L measured at screening
- Uncontrolled hypertension (systolic blood pressure \>120mmHg, diastolic blood pressure \>80mmHg) as defined by the average blood pressure measured at screening
- Weight gain or loss of \>10lbs in previous three months
- Consuming prescription or non-prescription drug, herbal or nutritional supplements known to affect outcome of the study as per investigator's judgement
Key Trial Info
Start Date :
April 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2028
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT06874400
Start Date
April 1 2025
End Date
April 1 2028
Last Update
March 13 2025
Active Locations (1)
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1
Nutrition Intervention Center
Toronto, Ontario, Canada, M5S 3H2