Status:
NOT_YET_RECRUITING
Identification of B Regulatory Cells by Flow Cytometry
Lead Sponsor:
Hull University Teaching Hospitals NHS Trust
Collaborating Sponsors:
Health Education England, Wessex
University of Manchester
Conditions:
Pollen Allergy
Venom Allergy
Eligibility:
All Genders
18+ years
Brief Summary
The goal of this laboratory and observational study is to develop a test to quantify B-regulatory cells in blood. This will be used to detect changes in B-regulatory cell populations in pollen and ins...
Detailed Description
Allergen immunotherapy (AIT) is a disease-modifying treatment for allergic disease which promotes immune system tolerance, i.e. reduces clinical manifestations of allergy and is the only known effecti...
Eligibility Criteria
Inclusion
- Control cohort - Participants with:
- No clinical and laboratory findings of IgE-mediated hypersensitivity (i.e. no clinical history of specific allergies to pollens, house dust mite or insect venoms
- Negative serological testing for specific IgE to pollens, house dust mite and insect venoms
- Patients aged 18 years or older
- Test cohort:
- Participants over the age of 18 years
- Participants with physician-diagnosed IgE-mediated allergic disease to pollens, house dust mite or insect venoms
- Exclusion Criteria:
- Patients under the age of 18 years
- Samples from patients with IgE-mediated allergic disease, treated or untreated, specific to allergens other than pollens, house dust mite and insect venom
- Participants who are pregnant
- Participants who cannot adequately understand verbal and / or written explanations given in English
Exclusion
Key Trial Info
Start Date :
February 1 2026
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 31 2027
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06876506
Start Date
February 1 2026
End Date
July 31 2027
Last Update
December 5 2025
Active Locations (1)
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1
Hull Teaching Hospital NHS Trust
Hull, East Yorkshire, United Kingdom, HU3 2JZ