Status:
NOT_YET_RECRUITING
Neurofilament Light Chain Correlation With Severity of Symptoms and Cognitive Decline in Mood Disorders
Lead Sponsor:
Assiut University
Conditions:
Mood Disorders
Eligibility:
All Genders
15-50 years
Brief Summary
* Explore correlation of neurofilament light chain serum level and severity of symptoms and cognitive impairment in mood disorders * Explore How novel brain markers as neurofilament light chain can be...
Detailed Description
Cytoskeletal integrity, represented by neurofilament light chain (NfL), has emerged as a critical biomarker for neuroaxonal injury, with growing evidence linking it to mood disorders such as major dep...
Eligibility Criteria
Inclusion
- Participants will be divided into three groups (A) Patients with Major depressive episode (B) Patients with Bipolar Disorder Manic Episode
- Inclusion criteria:
- age 15-50 years old
- both sexes will be included
- meet the Diagnostic And Statistical Manual Of Mental Disorders Fifth Edition (DSM-5) criteria for major depressive disorder or Bipolar disorder
- Exclusion criteria:
- Major Medical or Neurological Diseases.
- History of Traumatic Brain Injury, Major Fracture.
- Alcohol or Substance Use Disorder. (C) Healthy control
- a. Inclusion criteria:
- age- and sex-matching with group A, B
- Healthy Control without any of major physical conditions or psychiatric disorder
Exclusion
Key Trial Info
Start Date :
May 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2026
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT06877442
Start Date
May 1 2025
End Date
December 30 2026
Last Update
March 14 2025
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