Status:
COMPLETED
Nitrate - Clopidogrel - Acute Coronary Syndrome
Lead Sponsor:
Bursa Postgraduate Hospital
Conditions:
Acute Coronary Syndromes
Eligibility:
All Genders
18-75 years
Brief Summary
This study aims to investigate whether intravenous nitrate given during non-ST-elevation myocardial infarction (non-STEMI) affects the platelet inhibition of clopidogrel.
Eligibility Criteria
Inclusion
- diagnosed with non-STEMI
- Patients aged 18 to 75 years
- positive troponin levels,
- blood pressure above 120/70 mmHg
Exclusion
- Hemodynamically unstable and requiring urgent intervention,
- ST elevation on electrocardiography, atrial fibrillation,
- recurrent angina,
- use of narcotic analgesics (e.g., morphine), nitrates and glycoprotein IIb/IIIa inhibitors during hospitalization,
- history of coronary artery bypass graft (CABG) surgery,
- active infection,
- uncontrolled hypertension,
- diabetes, cerebrovascular accident, Use P2Y12 inhibitor, proton pump inhibitor, oral anticoagulant, statin, CYP enzyme-inducing or inhibiting drugs at the time of admission,
- active systemic disease (e.g., malignancy, thyroid disorders chronic inflammatory diseases, liver dysfunction),
- left ventricular systolic dysfunction (ejection fraction \<50%),
- glomerular filtration rate \<60 mL/min/1.73m2,
- allergy to ASA or clopidogrel, coagulopathy,
- platelet counts below 100,000/μl and hematocrit levels below 29%, or exceeding 52%.
Key Trial Info
Start Date :
February 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2024
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06878638
Start Date
February 1 2023
End Date
April 1 2024
Last Update
March 17 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Bursa Yüksek İhtisas Hastanesi
Bursa, Turkey (Türkiye), 16340