Status:
COMPLETED
Clinical Relevance of Major Pathologic Regression for Locally Advanced Rectal Cancer
Lead Sponsor:
Yanhong Deng
Conditions:
Rectal Neoplasms
Chemotherapy Effect
Eligibility:
All Genders
18-65 years
Brief Summary
We evaluated all related clinical and pathologic data of patients with Locally Advanced Rectal Cancer following Neoadjuvant Chemoradiotherapy, including the pathologic regression grading, and other hi...
Detailed Description
This large-scale, multi-center cohort study aims to investigate the clinical and prognostic implications of histopathologic characteristics in patients with Locally Advanced Rectal Cancer (LARC) follo...
Eligibility Criteria
Inclusion
- Adults (≥18 years) diagnosed with locally advanced rectal adenocarcinoma (clinical stage II-III).
- Completion of NCRT followed by curative-intent surgery. Availability of pre- and post-treatment histopathologic data, including standardized regression grading and digitized whole-slide images (WSIs).
Exclusion
- Metastatic disease at diagnosis. Incomplete clinical or pathologic records.
Key Trial Info
Start Date :
April 30 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 30 2023
Estimated Enrollment :
1187 Patients enrolled
Trial Details
Trial ID
NCT06879197
Start Date
April 30 2016
End Date
March 30 2023
Last Update
March 17 2025
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