Status:
RECRUITING
The Effect of CUGP Fluid Management in Patients With Sepsis or Septic Shock
Lead Sponsor:
Shusheng Li
Conditions:
Sepsis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study aims to assess whether procedural critical ultrasonography guided precise fluid management (CUGP) can affect the clinical fluid management strategy and improve the outcomes of patients with...
Detailed Description
This single-center parallel randomized controlled trial aims to assess whether procedural critical ultrasonography guided precise fluid management (CUGP) can affect the clinical fluid management strat...
Eligibility Criteria
Inclusion
- 1\. Age ≥ 18 years old;
- 2\. Estimated length of ICU stay ≥ 24 hours;
- 3\. Diagnosis according to the Sepsis 3.0 criteria, which included:
- a. suspected or confirmed infections supported by clinical evidence and/or positive microbiological findings;
- b. the sepsis related organ failure assessment (SOFA) score ≥ 2.
Exclusion
- 1\. Patients were pregnant woman;
- 2\. Patients had acute coronary syndrome;
- 3\. Patients had acute pulmonary edema;
- 4\. Patients had status asthmatics;
- 5\. Patients had malignant arrhythmia;
- 6\. Patients had active gastrointestinal bleeding;
- 7\. Patients had epileptic seizure;
- 8\. Patients had drug poisoning;
- 9\. Patients had severe burns;
- 10\. Patients had contraindications of blood transfusion;
- 11\. Patients had intra-abdominal hypertension (intra-abdominal pressure increases continuously ≥ 12mmHg);
- 12\. Patients had acute pulmonary embolism;
- 13\. Patients had contraindications of leg raising;
- 14\. Patients had cardiac structural or functional abnormalities (left ventricular outflow tract obstruction, moderate-to-severe mitral regurgitation, aortic regurgitation), it would seriously affect the velocity time integral of left ventricular outflow tract;
- 15\. Patients or their legal representatives refused active treatment;
- 16\. Patients or their legal representatives refused to participate in this study;
- 17\. Patients were participating in other interventional clinical trials.
Key Trial Info
Start Date :
April 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 31 2026
Estimated Enrollment :
118 Patients enrolled
Trial Details
Trial ID
NCT06879249
Start Date
April 1 2025
End Date
May 31 2026
Last Update
April 18 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China, 430030