Status:
COMPLETED
EVALUATION of GINGIVAL CREVICULAR FLUID and SERUM ASPROSIN LEVELS in OBESE and NORMAL-WEIGHT INDIVIDUALS with PERIODONTITIS
Lead Sponsor:
Gazi University
Collaborating Sponsors:
Gazi University Scientific Research Unit
Conditions:
Periodontitis
Obesity
Eligibility:
All Genders
18-65 years
Brief Summary
Obesity and periodontitis are chronic inflammatory diseases that share common pathological mechanisms. Asprosin, a novel adipokine discovered in 2016, has not been extensively studied in relation to p...
Eligibility Criteria
Inclusion
- Willingness to participate in the study.
- Weight classification:
- Obese individuals: Body mass index (BMI) of 30 kg/m² or higher.
- Normal-weight individuals: BMI between 18.5 and 24.9 kg/m².
- Periodontal health status:
- Bleeding on probing: less than 10%.
- Periodontal pocket depth: less than 3 mm.
- No sites showing attachment loss or alveolar bone loss on radiographs.
- For individuals with periodontitis:
- At least two non-adjacent teeth must show signs of interdental attachment loss.
- Periodontal pocket depth greater than 3 mm.
Exclusion
- Individuals who have received periodontal therapy, any oral decontamination treatment, or antibiotics or steroids in the six months prior to the start of the study.
- Individuals who are pregnant or breastfeeding.
- Individuals diagnosed with rheumatoid arthritis or lupus erythematosus.
- Individuals with a medical history of radiation or cancer therapy.
- Patients with diabetes, defined by:
- Hemoglobin A1c (HbA1c) level greater than 6.5%.
- Fasting blood glucose (FBG) greater than 126 mg/dL.
- An abnormal oral glucose tolerance test (OGTT).
- Smokers.
Key Trial Info
Start Date :
August 8 2023
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 10 2024
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06879951
Start Date
August 8 2023
End Date
August 10 2024
Last Update
March 17 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Gazi University Faculty of Dentistry
Ankara, Turkey (Türkiye), 06490