Status:
RECRUITING
Mitochondrial Function and Metabolomic Profile in Alzheimer's Disease and Related Dementias
Lead Sponsor:
Centre Hospitalier Universitaire de Nice
Conditions:
Alzheimer Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This project aims to study on one hand the early mitochondrial alterations, common or specific, occurring in peripheral cells of patients with Alzheimer's disease or related dementia and, on the other...
Detailed Description
Study will be proposed to the patient of the Nice Memory center who had a lumbar puncture and who agreed on the storage of a sample of their cerebrospinal fluid. Two groups of patients will be compar...
Eligibility Criteria
Inclusion
- Neurocognitive disorder with spontaneous complaint or reported for at least 6 months
- Diagnostic process according to current Haute Autorité de Santé (HAS) recommendations.
- cerebrospinal fluid biomarker dosage done within the study center and agreement to bio-collection of residual cerebrospinal fluid
- Patient having agreed to sign the informed consent
- Patient affiliated or beneficiary of a social security scheme
- For alzheimer group : diagnosis of Alzheimer's disease according to NIA-AA 2024 criteria (presence of a pathogenic amyloid process in the cerebrospinal fluid)
- For non alzheimer group : diagnosis of mild or major neurocognitive disorder according to Manuel diagnostique et statistique des troubles mentaux edition 5 (DSM-V) criteria, not linked to Alzheimer's disease (absence of pathogenic amyloid process in the cerebrospinal fluid)
Exclusion
- \- Vulnerable people
Key Trial Info
Start Date :
July 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2029
Estimated Enrollment :
170 Patients enrolled
Trial Details
Trial ID
NCT06880406
Start Date
July 1 2025
End Date
April 1 2029
Last Update
July 3 2025
Active Locations (1)
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1
CHU de Nice
Nice, PACA, France, 06000