Status:
RECRUITING
Affect-based Impulsivity in Borderline Personality Disorder
Lead Sponsor:
University of North Carolina, Chapel Hill
Collaborating Sponsors:
North Carolina Translational and Clinical Sciences Institute
Conditions:
Borderline Personality Disorder (BPD)
Healthy Controls Group - Age and Sex-matched
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
The purpose of this research study is to investigate how personality traits and neuroendocrine systems relate to decision-making patterns in individuals 18-45 years old. The main question it aims to a...
Eligibility Criteria
Inclusion
- Borderline Personality Disorder (BPD) group:
- Score of 38 or higher on Personality Assessment Inventory-Borderline Scale (PAI-BOR)
- Participants in the BPD group will be primarily recruited from the two
- DEPENd lab studies that maintain large samples of BPD participants. To ensure maximal similarity between BPD participants recruited from other DEPENd lab studies and BPD participants recruited through other recruitment sources, the investigators will use the same criteria for the BPD group in the current study as the criteria used in the other DEPENd lab studies. BPD participants in the two DEPENd lab studies from which the investigators will be recruiting must meet the following criteria:
- 3+ BPD symptoms, one of which must be affective instability, per clinical interview
- Participants must score at least 80 on the Reynolds Intellectual Screening Test (RIST).
- Health Control (HC) Group:
- Score of 12 or lower on PAI-BOR
- Score below 50th percentile on World Health Organization Disability Assessment Schedule (WHODAS)
- Absence of any current or lifetime psychiatric disorder, including personality disorders as determined by diagnostic interviews (SIDP and SCID), if the participant had participated in the lab's other studies (IRB Nos. 20-1735 and 21-0602).
- Combined
- Ages 18-45
- Provision of signed and dated informed consent form
- Stated willingness to comply with all study procedures and lifestyle considerations and availability for the duration of the study
- Willingness to participate in all components of the study
- Participants must be able to speak, understand and read English.
- Participants must have at least 20/40 visual acuity (correct or uncorrected).
Exclusion
- Use of as needed antihypertensive agents within 12 hours prior to lab visit
- Inability to refrain from using as needed psychotropic medications for 12 hours prior to lab visit
- History of psychotic disorder, Bipolar I disorder, autism spectrum disorder, reactive attachment disorder, pervasive developmental disorder, motor disorder, head injury, mental retardation, neurological disorder, or current substance dependence
- Family history of Bipolar I disorder in a first degree relative.
- Participants are also excluded for any of the following: cardiac pacemaker, aneurysm clip, cochlear implants, pregnancy, shrapnel, history of metal fragments in eyes, neurostimulators, weight of 250 lbs. or more, or claustrophobia.
Key Trial Info
Start Date :
September 21 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2026
Estimated Enrollment :
106 Patients enrolled
Trial Details
Trial ID
NCT06880640
Start Date
September 21 2025
End Date
August 1 2026
Last Update
September 24 2025
Active Locations (1)
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1
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27514