Status:
RECRUITING
Exploratory Study on the Efficacy of Betaine Hydrochloride in Treating Autoimmune Gastritis
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University
Conditions:
Autoimmune Gastritis
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Autoimmune gastritis (AIG) is a chronic autoimmune disorder characterized by parietal cell destruction and oxyntic mucosal atrophy, leading to achlorhydria and intrinsic factor deficiency. These patho...
Detailed Description
Autoimmune gastritis (AIG) is a chronic progressive autoimmune disorder characterized by the destruction of gastric parietal cells, leading to atrophy of the acid-secreting gastric mucosa. The loss of...
Eligibility Criteria
Inclusion
- Patients diagnosed with autoimmune gastritis at the Second Affiliated Hospital of Zhejiang University School of Medicine, with the diagnostic criteria for autoimmune gastritis based on the article "A real-world study on the characteristics of autoimmune gastritis: A single-center retrospective cohort in China" published by our team in the journal Clinics and Research in Hepatology and Gastroenterology;
- Gastrin levels greater than 300 pmol/L or a history of type 1 gastric neuroendocrine tumors or early gastric cancer treated with endoscopic submucosal dissection (ESD);
- Age between 18 and 80 years;
- Patients who have signed the informed consent form for the clinical trial.
Exclusion
- Patients allergic to betaine hydrochloride;
- Patients with peptic ulcers;
- Patients with any condition other than autoimmune gastritis that causes elevated gastrin levels (e.g., gastrinoma);
- Patients who refuse to sign the informed consent form.
Key Trial Info
Start Date :
January 3 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06881511
Start Date
January 3 2025
End Date
December 31 2026
Last Update
March 30 2025
Active Locations (1)
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1
The Second Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310009