Status:
RECRUITING
Immunomodulation During Pregnancy
Lead Sponsor:
Unidade Local de Saúde de Coimbra, EPE
Conditions:
Aspirin
Pregnancy Complications
Eligibility:
FEMALE
18+ years
Brief Summary
The goal of this observational study is to learn about the effects of low dose aspirin in immunity Pregnant women taking aspirin for other reasons (preeclampsia prevention) will be studied. The main q...
Detailed Description
The main objective of this study is to evaluate the effect of LDA on the modulation of innate immunity cells (NK cells, monocytes, γδ T cells) and/or acquired immunity (B and T lymphocytes, Treg cells...
Eligibility Criteria
Inclusion
- Singleton pregnancy
- Patients attending prenatal consultations at the Obstetrics Service A of CHUC, with the first consultation occurring before 14 weeks of gestation
- Gestational age determined by first-trimester ultrasound
- Study group: Women classified as high risk for PE according to clinical/historical criteria and the Fetal Medicine Foundation algorithm. LDA-naïve.
Exclusion
- Multiple pregnancy
- Autoimmune diseases
- Prior use of LDA or other immunomodulatory medication before potential recruitment
- History of spontaneous miscarriages and/or medical termination of pregnancy
- Fetal malformation
Key Trial Info
Start Date :
February 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 31 2025
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06882850
Start Date
February 1 2024
End Date
March 31 2025
Last Update
March 19 2025
Active Locations (1)
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1
Unidade Local de Saúde de Coimbra, E.P.E.
Coimbra, Coimbra District, Portugal, 3000-075