Status:
NOT_YET_RECRUITING
Effects of Vibrating Mesh Nebulisation in Patients With COPD During Non-invasive Ventilation (VMN-NIV)
Lead Sponsor:
Guy's and St Thomas' NHS Foundation Trust
Conditions:
COPD (Chronic Obstructive Pulmonary Disease)
Non-invasive Ventilation
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Assessment of the effects of vibrating mesh nebulisation versus jet nebulisation on the electrical activity of the muscles involved in breathing (neural respiratory drive), breathing mechanics (respir...
Detailed Description
Background Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality in the United Kingdom. Acute exacerbations of COPD (AECOPD) frequently necessitate hospitalis...
Eligibility Criteria
Inclusion
- Patients with COPD receiving home non-invasive ventilation for chronic respiratory failure under the Lane Fox Respiratory Service at Guy's and St Thomas' NHS Foundation Trust
- Tolerating home non-invasive ventilation for at least 4 hours/24 hours
- Aged 18-80 years old
- Able to communicate symptom burden to the research team
- Able to give informed consent for participation in the study
- Clinical stability, with no acute exacerbations of COPD for 2 weeks prior to enrolment
Exclusion
- Severe, non-respiratory organ dysfunction including, but not limited to:
- Congestive cardiac failure
- Significant cardiovascular disease
- End-stage malignancy
- End-stage renal failure
- Acute pulmonary pathology requiring emergency treatment including, but not limited to:
- Pneumonia
- Pneumothorax
- Pulmonary embolism
- Severe cognitive impairment
- Psychosocial factors that would preclude completion of the study protocol
Key Trial Info
Start Date :
March 21 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2026
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT06884228
Start Date
March 21 2025
End Date
May 1 2026
Last Update
March 19 2025
Active Locations (1)
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1
Lane Fox Unit, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust
London, United Kingdom, SE1 7EH