Status:
RECRUITING
Personalised HeartCare: Poligenic Risk Scores Disclosure for Cardiovascular Prevention
Lead Sponsor:
Catholic University of the Sacred Heart
Conditions:
Cardiovascular Diseases
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
The goal of this clinical trial is to evaluate whether the disclosure of Polygenic Risk Scores (PRS) combined with personalized coaching on risk factors can lead to significant improvements in lifesty...
Detailed Description
This study aims to evaluate the efficacy of disclosing cardiovascular genetic risk-specifically through the Polygenic Risk Score (PRS)-in promoting the adoption of healthier lifestyle behaviors. The ...
Eligibility Criteria
Inclusion
- Inclusion criteria
- Traditional cardiovascular risk: The risk will be assessed using SCORE 2 (low risk \< 2.5%, moderate risk between 2.5% and 5%, high risk between 5% and 10%) or SCORE 2-OP (moderate risk \< 7.5%, high risk between 7.5% and 15%).
- Blood tests: Participants must have had blood tests performed within the past 6 months.
- Age: Participants must be at least 40 years old.
- Exclusion Criteria
- Very high cardiovascular risk, as measured by SCORE 2 (very high risk \> 10%) or SCORE 2-OP (very high risk \> 15%).
- Diabetes.
- Familial hypercholesterolemia.
- Previous cardiovascular events or established CVD
Exclusion
Key Trial Info
Start Date :
June 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
650 Patients enrolled
Trial Details
Trial ID
NCT06888466
Start Date
June 1 2025
End Date
December 1 2026
Last Update
September 22 2025
Active Locations (1)
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1
Dipartimento Universitario di Scienze della Vita e Sanità Pubblica
Roma, Italia, Italy, 00168